4-Chlorobenzotrifluoride

4-Chlorobenzotrifluoride
Names
Preferred IUPAC name
1-Chloro-4-(trifluoromethyl)benzene
Other names
  • Benzene, 1-chloro-4-(trifluoromethyl)-
  • Parachlorobenzotrifluoride
  • 4-Chlorobenzotrifluoride
  • Oxsol
Identifiers
CAS Number
3D model (JSmol)
Abbreviations PCBTF
Beilstein Reference
 510203
ChemSpider
ECHA InfoCard 100.002.438
EC Number
  • 202-681-1202-681-1
MeSH C037723
PubChem CID
UNII
UN number 2234
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C7H4ClF3/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H ☒N
    Key: QULYNCCPRWKEMF-UHFFFAOYSA-N ☒N
  • InChI=1/C7H4ClF3/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H
    Key: QULYNCCPRWKEMF-UHFFFAOYAI
SMILES
  • C1=CC(=CC=C1C(F)(F)F)Cl
Properties
Chemical formula
 C7H4ClF3
Molar mass 180.55 g·mol−1
Appearance Colorless liquid
Density 1.33-1.35 @ 22 °C (72 °F)[1]
Melting point −32.8 °C (−27.0 °F; 240.3 K) [1]
Boiling point 138.6 °C (281.5 °F; 411.8 K) [1]
Solubility in water
 29 mg/L
log P 3.7 @ 25 °C (77 °F)
Vapor pressure 5.3 millimetres of mercury (0.0070 atm) @ 20 °C (68 °F)[1]
Henry's law
constant (kH)
 0.0347
Hazards
GHS labelling:
Pictograms
 GHS02: FlammableGHS07: Exclamation markGHS09: Environmental hazard
Signal word
 Warning
Hazard statements
 H226, H315, H319, H335, H411
Precautionary statements
 P210, P233, P240, P241, P242, P243, P261, P264, P271, P273, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P391, P403+P233, P403+P235, P405, P501
NFPA 704 (fire diamond)
NFPA 704 four-colored diamond
1
2
1
Flash point 42.8 °C (109.0 °F; 315.9 K)
Autoignition
temperature
 600 °C (1,112 °F; 873 K)
Explosive limits 0.9%-10.5% (V)[1]
Lethal dose or concentration (LD, LC):
LD50 (median dose)
  • Oral, rat: 13000 mg/kg
  • Dermal, rabbit: > 2000 mg/kg
LC50 (median concentration)
 Inhalation, rat: 33 mg/L
Safety data sheet (SDS) https://smc-global.com/wp-content/uploads/2020/07/SMC-msds_m900.pdf
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

4-Chlorobenzotrifluoride is a organofluorine compound with the molecular formula C7H4ClF3. Frequently abbreviated PCBTF (for parachlorobenzotrifluoride), it is a colorless liquid with a distinct aromatic odor. PCBTF has been commercially-produced since the 1960s. It is a precursor to commercial dyes.[2]

Preparation

4-Chlorobenzotrifluoride is produced commercially by trifluoromethylation of chlorobenzene.[2]

Historically, Occidental Chemical Corporation was a leading producer and sold it as part of its Oxsol product line, specifically under the brand name of Oxsol 100.[3] Occidental Chemical Corporation sold the OXSOL line to Makhteshim Agan Industries, Ltd., in 2002.[4]

Uses

Nitration of PCBTF gives 4-chloro-3,5-dinitrobenzotrifluoride, a precursor to the herbicides trifluralin, fluorodifen, and acifluorfen. It is also a precursor to the insecticide fluvalinate.[2]

PCBTF has also been used as a solvent.[5]

Health and Environmental effects

Health effects:

  • Points of entry: eyes, ingestion, inhalation, skin.
  • Target organs: central nervous system, kidneys, liver.
  • Irritancy: eyes, respiratory tract, skin[3]

In the troposphere, PCBTF has an estimated half-life of 67 days. It is transformed by reaction with photochemically-produced hydroxyl radicals to give mainly 2-chloro-5-trifluoromethylphenol.[5]

Regulation

PCBTF currently has VOC Exempt status from the U.S. Environmental Protection Agency.[6] However, California's Office of Environmental Health Hazard Assessment (OEHHA) has adopted inhalation risk factors for PCBTF as of June 2019, which could have implications for its ongoing VOC Exempt status.[7][8]

References

  1. ^ a b c d e "PCBTF 900, Technical Grade, Liquid, Bulk Datasheet". UnivarSolutions. Retrieved 13 November 2024.
  2. ^ a b c Siegemund, Günter; Schwertfeger, Werner; Feiring, Andrew; Smart, Bruce; Behr, Fred; Vogel, Herward; McKusick, Blaine; Kirsch, Peer (2016). "Fluorine Compounds, Organic". Ullmann's Encyclopedia of Industrial Chemistry. pp. 1–56. doi:10.1002/14356007.a11_349.pub2. ISBN 978-3-527-30673-2..
  3. ^ a b "MSDS provided by Islechem" (PDF). Archived from the original (PDF) on 2021-12-26. Retrieved 2021-12-23.
  4. ^ "Trifluoromethylbenzene 98-08-8" (PDF). National Cancer Institute. Archived from the original (PDF) on September 9, 2015. Retrieved 14 December 2022.
  5. ^ a b Rayner-Canham, Geoff (March 2014). "Para-Chlorobenzotrifluoride (PCBTF) – the 'super-solvent'". Chem 13 News Magazine. The University of Waterloo. Retrieved 14 December 2022.
  6. ^ "EPA Exempt Volatile Organic Compound: Parachlorobenzotrifluoride" (PDF). American Coatings Association. 2018-01-30. Retrieved 2019-03-20.
  7. ^ "Chemical Listed Effective June 28, 2019 as Known to the State Of California To Cause Cancer: P-Chloro-a,a,a-Trifluorotoluene (Para-Chlorobenzotrifluoride, PCBTF)". oehha.ca.gov. Retrieved 2021-08-14.
  8. ^ p-Chloro-α,α,α-trifluorotoluene (p-Chlorobenzotrifluoride, PCBTF) - Cancer Inhalation Unit Risk Factor Scientific Review Panel Draft - January 2020 - California Office of Environmental Health Hazard Assessment
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