2,4-Dichlorobenzyl alcohol
2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. It is a common ingredient in throat lozenges such as Cofsils, Strepsils, Lorsept, and Gorpils. A low-pH throat lozenge containing dichlorobenzyl alcohol (1.2 mg) and amylmetacresol (0.6 mg) has been found to deactivate respiratory syncytial virus and SARS-Cov, but not adenovirus or rhinovirus.[1] A dentifrice containing 10% sodium benzoate and 0.3% dichlorobenzyl alcohol maintains antimicrobial activity for 5 to 10 minutes after brushing.[2]
 | |
| Names | |
|---|---|
| IUPAC name
(2,4-Dichlorophenyl)methanol | |
| Other names
Dybenal Rapidosept Myacide SP | |
| Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.015.646 |
PubChem CID |
|
| UNII | |
CompTox Dashboard (EPA) |
|
InChI
| |
SMILES
| |
| Properties | |
Chemical formula |
C7H6Cl2O |
| Molar mass | 177.02 g·mol−1 |
| Melting point | 57 to 60 °C (135 to 140 °F; 330 to 333 K) |
| Boiling point | 150 °C (302 °F; 423 K) 25 mmHg |
| Pharmacology | |
ATC code |
R02AA03 (WHO) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
  | |
| Infobox references | |
It is an ingredient in the European product Neo Borocillina.[3]
References
- Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antiviral Chemistry & Chemotherapy. 16 (2): 129–34. doi:10.1177/095632020501600205. PMID 15889535.
- Ostergaard E (1994). "Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study". Acta Odontol Scand. 52 (6): 335–45. doi:10.3109/00016359409029031. PMID 7887143.
- "Neo Borocillina". drugs.com.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.