Metergoline
Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.[1][2]
![]() | |
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider |
|
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.037.881 ![]() |
Chemical and physical data | |
Formula | C25H29N3O2 |
Molar mass | 403.526 g·mol−1 |
3D model (JSmol) | |
SMILES
| |
InChI
| |
![]() ![]() |
References
- Hamon M, Mallat M, Herbet A, et al. (February 1981). "[3H]Metergoline: a new ligand of serotonin receptors in the rat brain". Journal of Neurochemistry. 36 (2): 613–26. doi:10.1111/j.1471-4159.1981.tb01634.x. PMID 7463079.
- Miller KJ, King A, Demchyshyn L, Niznik H, Teitler M (1992). "Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan". Eur. J. Pharmacol. 227 (1): 99–102. doi:10.1016/0922-4106(92)90149-P. PMID 1330643.
External links
- Metergoline at the US National Library of Medicine Medical Subject Headings (MeSH)
Tocolytics/labor repressants (G02CA) | |
---|---|
β2 adrenoreceptor agonists |
|
Oxytocin antagonists |
|
NSAIDs | |
Calcium channel blockers | |
Myosin inhibitors |
Dopamine receptor modulators | |||||
---|---|---|---|---|---|
D1-like |
| ||||
D2-like |
| ||||
|
Serotonin receptor modulators | |||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-HT1 |
| ||||||||||||||||||||||||||||||||||||||
5-HT2 |
| ||||||||||||||||||||||||||||||||||||||
5-HT3–7 |
| ||||||||||||||||||||||||||||||||||||||
|
Ergolines | |
---|---|
Lysergic acid derivatives |
|
Psychedelic lysergamides |
|
Clavines |
|
Other ergolines |
|
Natural sources |
Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui) |