Pegaspargase

Pegaspargase, sold under the trade name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL).[1] Often it is used together with anthracycline, vincristine, and prednisone.[2] It is used by injection.[2]

Pegaspargase
Clinical data
Pronunciation/pəˈɡæspərɡeɪz/
Trade namesOncaspar
AHFS/Drugs.comMonograph
MedlinePlusa695031
License data
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		Intramuscular injection (IM), intravenous (IV)
    ATC code
    Legal status
    Legal status
    • US: ℞-only
    Identifiers
    CAS Number
    DrugBank
    ChemSpider
    • none
    UNII
    Chemical and physical data
    FormulaC1377H2208N382O442S17
    Molar mass31732.06 g·mol−1
     NY (what is this?)  (verify)

    Common side effects include allergic reactions, blood clotting problems, high blood sugar, liver problems, pancreas inflammation, and blood clots in the brain.[2] Its use during pregnancy may harm the baby.[3] It is a modified version of the enzyme asparaginase which has undergone PEGylation.[4][2] It works by breaking down asparagine, decreasing its availability to make protein.[2]

    Pegaspargase was approved for medical use in the United States in 1994.[2] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[5] It is made by Sigma-Tau.[2] In the United States it costs about $US17,800 per 3750 units vial.[6]

    References
    1. Graham ML (2003). "Pegaspargase: a review of clinical studies". Adv. Drug Deliv. Rev. 55 (10): 1293–302. doi:10.1016/S0169-409X(03)00110-8. PMID 14499708.
    2. "Pegaspargase Monograph for Professionals". Drugs.com. Retrieved 11 October 2019.
    3. "Pegaspargase (Oncaspar) Use During Pregnancy". Drugs.com. Retrieved 11 October 2019.
    4. "UNM Cancer Center". Archived from the original on 3 September 2006. Retrieved 28 August 2007.
    5. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    6. "Oncaspar Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 11 October 2019.
    • "Pegaspargase". Drug Information Portal. U.S. National Library of Medicine.


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