Antazoline
Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.[1] To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline.[2] The drug is a Histamine H1 receptor antagonist:[3] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
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| Trade names | Vasocon-a |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Topical (nasal, eye drops) |
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| ECHA InfoCard | 100.001.904  |
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| Formula | C17H19N3 |
| Molar mass | 265.360 g·mol−1 |
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References
- Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. doi:10.1016/s0002-9394(14)74864-0. PMID 7425039.
- Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis" (PDF). Cochrane Database Syst Rev. 6: CD009566. doi:10.1002/14651858.CD009566.pub2. PMID 26028608.
- Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.
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