Phenylpiperazine

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.[1]

Phenylpiperazine
Names
IUPAC name
1-phenylpiperazine
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.001.969
PubChem CID
UNII
CompTox Dashboard (EPA)
Properties
Chemical formula
 C10H14N2
Molar mass 162.23 g/mol
Appearance clear colourless to yellow liquid
Density 1.028g/cm3
Melting point 18.8 °C (65.8 °F; 291.9 K)
Boiling point 287.2 °C (549.0 °F; 560.3 K) at 760mmHg
Solubility in water
 insoluble
Hazards
Flash point 138.3 °C (280.9 °F; 411.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

A number of phenylpiperazine derivatives are drugs, including:

Pharmaceuticals:

  • Antrafenine — anti-inflammatory
  • Aripiprazole — antipsychotic
  • Bifeprunox — antipsychotic
  • Brexpiprazole — antipsychotic
  • Cariprazine — antipsychotic
  • Ciprofloxacin — antibiotic
  • Dapiprazole — alpha blocker
  • Dropropizine — antitussive
  • Elopiprazole — antipsychotic
  • Etoperidone — antidepressant
  • Itraconazole — antifungal
  • Ketoconazole — antifungal
  • Levodropropizine — antitussive
  • Mepiprazole — anxiolytic
  • Mianserin — antidepressant
  • Naftopidil — antihypertensive
  • Nefazodone — antidepressant
  • Niaprazine — hypnotic
  • Oxypertine — antipsychotic
  • Posaconazole — antifungal
  • Tioperidone — antipsychotic
  • Tolpiprazole — anxiolytic
  • Trazodone — antidepressant
  • Umespirone — antipsychotic
  • Urapidil — antihypertensive
  • Vesnarinone — cardiotonic
  • Vortioxetine — antidepressant

Research chemicals:

  • Acaprazine — anxiolytic
  • Batoprazine — serenic (antiaggressive)
  • Bifeprunox — antipsychotic
  • BRL-15,572 — serotonergic
  • CSP-2503 — anxiolytic
  • DMPP — nicotinic
  • EGIS-12,233 — serotonergic
  • Elopiprazole — antipsychotic
  • Eltoprazine — serenic
  • Enciprazine — anxiolytic
  • Enpiprazole — anxiolytic
  • Ensaculin — nootropic
  • Flibanserin — aphrodisiac
  • Fluprazine — serenic
  • Flesinoxan — antidepressant
  • Lorpiprazole — anxiolytic
  • Naluzotan — antidepressant
  • Naphthylpiperazine — serotonergic
  • Pardoprunox — antiparkinsonian
  • S-14,506 — serotonergic
  • S-14,671 — serotonergic
  • S-15,535 — serotonergic
  • SB-258,585 — serotonergic
  • SB-271,046 — serotonergic
  • SB-357,134 — serotonergic
  • SB-399,885 — serotonergic
  • Sonepiprazole — dopaminergic
  • Tolpiprazole — anxiolytic
  • Vilazodone — antidepressant
  • Vortioxetine — antidepressant
  • WAY-100,135 — serotonergic
  • WAY-100,635 — serotonergic
  • Zolertine — antihypertensive

Designer drugs:

  • 2C-B-PP — serotonergic
  • 3,4-CFP — serotonergic
  • DCPP — serotonergic
  • mCPP — serotonergic
  • MeOPP — serotonergic
  • pCPP — serotonergic
  • pFPP — serotonergic
  • TFMPP — serotonergic

See also

References
  1. World Health Organization (WHO) (2006). "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Retrieved 27 April 2010.


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