Desmosterol

Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis.[1] 24-dehydrocholesterol reductase catalyses the reduction of desmosterol to cholesterol.[2] It is accumulated in desmosterolosis.

Desmosterol

Names
IUPAC name (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Other names Cholesta-5,24-dien-3β-ol
Identifiers
CAS Number	313-04-2 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:17737 Y
ChEMBL	ChEMBL455876 Y
ChemSpider	388662 Y
ECHA InfoCard	100.005.671
IUPHAR/BPS	2748
PubChem CID	439577
UNII	ANP93865R8 Y
CompTox Dashboard (EPA)	DTXSID10878676
InChI InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 Y Key: AVSXSVCZWQODGV-DPAQBDIFSA-N Y InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 Key: AVSXSVCZWQODGV-DPAQBDIFBV
SMILES O[C@@H]4C/C3=C/C[C@@H]1[C@H](CC[C@]2([C@H]1CC[C@@H]2[C@H](C)CC\C=C(/C)C)C)[C@@]3(C)CC4
Properties
Chemical formula	C27H44O
Molar mass	384.64 g/mol
Appearance	White powder
Melting point	121.5 °C (250.7 °F; 394.6 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

In 2014, it was named the Molecule of the Year 2012 by the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR).[3]