Choline theophyllinate |
|
| Trade names | Choledyl, Theocolin |
|---|
| Other names | Oxtriphylline |
|---|
| AHFS/Drugs.com | International Drug Names |
|---|
| ATC code | |
|---|
|
| Excretion | mainly via kidneys |
|---|
|
(2-Hydroxyethyl)trimethylazanium; 1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-ide
|
| CAS Number | |
|---|
| PubChem CID | |
|---|
| DrugBank | |
|---|
| ChemSpider | |
|---|
| UNII | |
|---|
| KEGG | |
|---|
| ChEMBL | |
|---|
| CompTox Dashboard (EPA) | |
|---|
| ECHA InfoCard | 100.022.545 |
|---|
|
| Formula | C12H21N5O3 |
|---|
| Molar mass | 283.332 g·mol−1 |
|---|
| 3D model (JSmol) | |
|---|
Cn1c(c-2ncnc2n(c1=O)C)[O-].C[N+](C)(C)CCO
|
InChI=1S/C7H8N4O2.C5H14NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-6(2,3)4-5-7/h3,12H,1-2H3;7H,4-5H2,1-3H3/q;+1/p-1 Key:SOELXOBIIIBLRJ-UHFFFAOYSA-M
|
Choline theophyllinate (INN), also known as oxtriphylline, is a cough medicine derived from xanthine that acts as a bronchodilator to open up airways in the lung. Chemically, it is a salt of choline and theophylline. It classifies as an expectorant. The drug is available under the brand names Choledyl and Choledyl SA, among others.[1]
References
Drugs for obstructive airway diseases: asthma/COPD (R03) |
|---|
| Adrenergics, inhalants | | Short-acting β2 agonists | |
|---|
| Long-acting β2 agonists | |
|---|
| Ultra-long-acting β2 agonists |
- Abediterol
- Carmoterol
- Indacaterol
- Olodaterol
- Vilanterol
|
|---|
| Other | |
|---|
|
|---|
| Glucocorticoids | |
|---|
Anticholinergics/ muscarinic antagonist | |
|---|
| Mast cell stabilizers | |
|---|
| Xanthines | |
|---|
| Eicosanoid inhibition | | Leukotriene antagonists | |
|---|
| Arachidonate 5-lipoxygenase inhibitors | |
|---|
| Thromboxane receptor antagonists | |
|---|
| Non-xanthine PDE4 inhibitors | |
|---|
|
|---|
| Others/unknown | |
|---|
| Combination products |
- Aclidinium bromide/formoterol
- Beclometasone/formoterol
- Beclometasone/formoterol/glycopyrronium bromide
- Budesonide/formoterol
- Budesonide/glycopyrronium bromide/formoterol
- Fluticasone furoate/umeclidinium bromide/vilanterol
- Fluticasone furoate/vilanterol
- Fluticasone propionate/salmeterol
- Glycopyrronium bromide/formoterol
- Indacaterol/glycopyrronium bromide
- Indacaterol/glycopyrronium bromide/mometasone
- Indacaterol/mometasone
- Ipratropium bromide/salbutamol
- Mometasone/formoterol
- Salbutamol (albuterol)/budesonide
- Theophylline/ephedrine
- Theophylline/ephedrine/hydroxyzine
- Theophylline/ephedrine/phenobarbital
- Umeclidinium bromide/vilanterol
|
|---|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
Phosphodiesterase inhibitors |
|---|
| PDE1 | |
|---|
| PDE2 |
- BAY 60-7550
- Carbazeran
- EHNA
- Oxindole
- PDP
|
|---|
| PDE3 | |
|---|
| PDE4 |
- Apremilast
- Arofylline
- Atizoram
- Benafentrine
- Catramilast
- CC-1088
- CDP-840
- CGH-2466
- Cilomilast
- Cipamfylline
- Crisaborole
- Denbutylline
- Difamilast
- Drotaverine
- Ensifentrine
- Etazolate
- Filaminast
- Glaucine
- HT-0712
- ICI-63197
- Indimilast
- Irsogladine
- Lavamilast
- Lirimilast
- Lotamilast
- Luteolin
- Mesembrenone
- Mesembrine
- Mesopram
- Oglemilast
- Piclamilast
- Pumafentrine
- Revamilast
- Ro 20-1724
- Roflumilast
- Rolipram
- Ronomilast
- RPL-554
- RS-25344
- Tetomilast
- Tofimilast
- YM-976
- Zardaverine
|
|---|
| PDE5 |
- Acetildenafil
- Aildenafil
- Avanafil
- Beminafil
- Benzamidenafil
- Dasantafil
- Icariin
- Gisadenafil
- Homosildenafil
- Lodenafil
- Mirodenafil
- MY-5445
- Nitrosoprodenafil
- Norcarbodenafil
- SCH-51866
- Sildenafil
- Sulfoaildenafil
- T-0156
- Tadalafil
- Udenafil
- Vardenafil
|
|---|
| PDE7 | |
|---|
| PDE9 | |
|---|
| PDE10 |
- Balipodect
- Mardepodect
- MK-8189
- Papaverine
- TC-E 5005
- Tofisopam
|
|---|
| PDE11 | BC11-38 |
|---|
| Non-selective | |
|---|
| Unsorted | |
|---|
See also: Receptor/signaling modulators |
Purine receptor modulators |
|---|
Receptor (ligands) | |
|---|
Transporter (blockers) | | CNTsTooltip Concentrative nucleoside transporters | |
|---|
| ENTsTooltip Equilibrative nucleoside transporters | |
|---|
| PMATTooltip Plasma membrane monoamine transporter | |
|---|
|
|---|
Enzyme (inhibitors) | | XOTooltip Xanthine oxidase | |
|---|
| Others | |
|---|
|
|---|
| Others | |
|---|
See also: Receptor/signaling modulators |