Antrafenine
Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.
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| Routes of administration | Oral |
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| Metabolism | Hepatic |
| Excretion | Renal |
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| Formula | C30H26F6N4O2 |
| Molar mass | 588.554 g·mol−1 |
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See also
- Phenylpiperazine
- Trifluoromethylphenylpiperazine
References
- Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
- Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.
Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA) | |
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| N-Arylanthranilic acids (fenamates) |
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Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use medications. | |
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| Simple piperazines (no additional rings) |
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| Phenylpiperazines |
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| Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
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| Pyrimidinylpiperazines |
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| Pyridinylpiperazines |
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| Benzo(iso)thiazolylpiperazines |
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| Tricyclics (piperazine attached via side chain) |
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