Meglutol (INN, also known as 3-hydroxy-3-methylglutaric acid, β-hydroxy-β-methylglutaric acid, and dicrotalic acid) is a hypolipidemic agent.
It occurs free in Crotalaria dura and C. globifera and is bound in dicrotaline (pyrrolizidine alkaloid).
See also
- Crotalaria
- List of Crotalaria species
- Mevalonic acid
Lipid-lowering agents (C10) |
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| GI tract | | Cholesterol absorption inhibitors, NPC1L1 | |
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| Bile acid sequestrants/resins (LDL) | |
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| Liver | | Statins (HMG-CoA reductase, LDL) | |
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| Niacin and derivatives (HDL and LDL) | |
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| MTTP inhibitors (VLDL) |
- Dirlotapide
- Lomitapide
- Mitratapide
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| ATP citrate lyase inhibitors (LDL) | |
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| Thyromimetics (VLDL) | |
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| Blood vessels | | PPAR agonists (LDL) | |
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| CETP inhibitors (HDL) |
- Anacetrapib†
- Dalcetrapib§
- Evacetrapib§
- Obicetrapib†
- Torcetrapib§
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| PCSK9 inhibitors (LDL) |
- Alirocumab
- Bococizumab
- Enlicitide†
- Evolocumab
- Inclisiran
- Lerodalcibep
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| ANGPTL3 inhibitors (LDL/HDL) | |
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| Combinations |
- Amlodipine/atorvastatin
- Bempedoic acid/ezetimibe
- Ezetimibe/atorvastatin
- Ezetimibe/rosuvastatin
- Ezetimibe/simvastatin
- Fenofibrate/pravastatin
- Fenofibrate/simvastatin
- Niacin/laropiprant
- Niacin/lovastatin
- Niacin/simvastatin
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| Other |
- Alipogene tiparvovec
- Azacosterol
- Azalanstat
- Benfluorex‡
- Darapladib§
- Lapaquistat§
- Magnesium pyridoxal 5-phosphate glutamate
- Meglutol
- Mipomersen
- Olezarsen
- Omega−3-acid ethyl esters
- Plozasiran
- Policosanol
- Probucol
- Tiadenol
- Triparanol‡
- Volanesorsen
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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