Trimedoxime bromide |
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Routes of administration | Intramuscular injection |
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| ATC code | |
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| Legal status |
- Experimental; in military use
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| Elimination half-life | 2 hours (mean) |
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1,1′-propane-1,3-diylbis{4-[(E)-(hydroxyimino)methyl]pyridinium} dibromide
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| CAS Number | |
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| PubChem CID | |
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| ChemSpider | |
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| UNII | |
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| CompTox Dashboard (EPA) | |
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| ECHA InfoCard | 100.000.276 |
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| Formula | C15H18Br2N4O2 |
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| Molar mass | 446.143 g·mol−1 |
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Trimedoxime bromide (INN), also known as dipyroxime or TMB-4, is an oxime used in the treatment of organophosphate poisoning[1] It is chemically related to asoxime, pralidoxime, and obidoxime.[2]
References
Antidotes (V03AB) |
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Nervous system | | Alcohol intoxication | |
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Barbiturate overdose | |
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Benzodiazepine overdose | |
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| GHB overdose | |
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Nerve agent / Organophosphate poisoning | |
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| Opioid overdose | |
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Reversal of neuromuscular blockade | |
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Circulatory system | | Beta blocker | |
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| Digoxin toxicity | |
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| Anticoagulants |
- against direct Xa inhibitors (Andexanet alfa)
- against heparin (Protamine#)
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| Other | | Arsenic poisoning | |
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| Cyanide poisoning | |
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| Hydrofluoric acid | |
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Methanol / Ethylene glycol poisoning | |
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Paracetamol toxicity (Acetaminophen) | |
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| Toxic metals (cadmium
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| Other |
- iodine-131
- Methylthioninium chloride#
- oxidizing agent
- Prednisolone/promethazine
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| Emetic | |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Enzyme (modulators) | | ChATTooltip Choline acetyltransferase |
- Inhibitors: 1-(-Benzoylethyl)pyridinium
- 2-(α-Naphthoyl)ethyltrimethylammonium
- 3-Chloro-4-stillbazole
- 4-(1-Naphthylvinyl)pyridine
- Acetylseco hemicholinium-3
- Acryloylcholine
- AF64A
- B115
- BETA
- CM-54,903
- N,N-Dimethylaminoethylacrylate
- N,N-Dimethylaminoethylchloroacetate
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| AChETooltip Acetylcholinesterase | |
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| BChETooltip Butyrylcholinesterase | |
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Transporter (modulators) | | CHTTooltip Choline transporter |
- Inhibitors: Hemicholinium-3 (hemicholine)
- Triethylcholine
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| VAChTTooltip Vesicular acetylcholine transporter | |
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Release (modulators) | | Inhibitors |
- Others: Bungarotoxins (β-bungarotoxin, γ-bungarotoxin)
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| Enhancers |
- LPHNTooltip Latrophilin agonists: α-Latrotoxin
- Others: Atracotoxins (e.g., robustoxin, versutoxin)
- Crotoxin
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- See also
- Receptor/signaling modulators
- Muscarinic acetylcholine receptor modulators
- Nicotinic acetylcholine receptor modulators
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