Cyclazocine

Cyclazocine
Clinical data
Routes of
administration		By mouth
ATC code
  • none
Identifiers
IUPAC name
  • 3-(Cyclopropylmethyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
    or
    2-Cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.627
Chemical and physical data
FormulaC18H25NO
Molar mass271.404 g·mol−1
3D model (JSmol)
SMILES
  • Oc1ccc4c(c1)C2(C(C(N(CC2)CC3CC3)C4)C)C
InChI
  • InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3 checkY
  • Key:YQYVFVRQLZMJKJ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. It is in the benzomorphan and benzazocine family of drugs.[1] It is a κ-opioid receptor agonist and μ-opioid receptor partial agonist, and also has high affinity for the δ-opioid receptor.[2]

Research

Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and colleagues (1970). It showed that 8 out of 10 patients experienced moderate improvement.

Research during the 1960s and 1970s into the possible use of cyclazocine for management of pain, and later for assisting treatment of opioid addiction was severely hampered by the drug's psychotomimetic, dysphoric, and hallucinatory effects.[3] The dysphoric/anxiety-inducing effects of the drug correlate with increasing dosage and would likely reduce the risk of abuse in the same manner as other opioids which preferentially act on the KOR versus the DOR and MOR, although the side-effect threshold is often lower than the lowest effective dose.

References

  1. ^ Archer S, Glick SD, Bidlack JM (November 1996). "Cyclazocine revisited". Neurochemical Research. 21 (11): 1369–1373. doi:10.1007/BF02532378. PMID 8947927. S2CID 680860.
  2. ^ Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP (July 2002). "8-Carboxamidocyclazocine: a long-acting, novel benzomorphan". The Journal of Pharmacology and Experimental Therapeutics. 302 (1): 374–380. doi:10.1124/jpet.302.1.374. PMID 12065740. S2CID 15864569.
  3. ^ Freedman AM, Fink M, Sharoff R, Zaks A (October 1967). "Cyclazocine and methadone in narcotic addiction". JAMA. 202 (3): 191–194. doi:10.1001/jama.1967.03130160065011. PMID 6072354.
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