Masoprocol

Masoprocol
Clinical data
Trade names	Actinex
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	L01XX10 (WHO) ;
Pharmacokinetic data
Bioavailability	Very low
Identifiers
	IUPAC name 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol;
CAS Number	27686-84-6 ;
PubChem CID	71398;
IUPHAR/BPS	4265;
DrugBank	DB00179 ;
ChemSpider	64490 ;
UNII	7BO8G1BYQU;
ChEBI	CHEBI:73468 ;
ChEMBL	ChEMBL313972 ;
CompTox Dashboard (EPA)	DTXSID5045178 ;
ECHA InfoCard	100.044.172
Chemical and physical data
Formula	C18H22O4
Molar mass	302.370 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2;
	InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ ; Key:HCZKYJDFEPMADG-TXEJJXNPSA-N ;
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Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. It is the meso form of nordihydroguaiaretic acid that is taken by mouth. The substance is being studied in the treatment of prostate cancer.

Masoprocol is also called NDGA, and Actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.^[1]

References

^ Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

External links

MedlinePlus Drug Information
Actinex entry in the public domain NCI Cancer Dictionary

[1] Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

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