Rolicyclidine |
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| Legal status |
- AU: S9 (Prohibited substance)
- BR: Class F2 (Prohibited psychotropics)[1]
- CA: Schedule III
- DE: Anlage I (Authorized scientific use only)
- UK: Class A
- US: Schedule I
- UN: Psychotropic Schedule I
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1-(1-phenylcyclohexyl)pyrrolidine
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| Formula | C16H23N |
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| Molar mass | 229.367 g·mol−1 |
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| 3D model (JSmol) | |
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c1ccccc1C3(N2CCCC2)CCCCC3
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InChI=1S/C16H23N/c1-3-9-15(10-4-1)16(11-5-2-6-12-16)17-13-7-8-14-17/h1,3-4,9-10H,2,5-8,11-14H2 YKey:FYOWWXMGDATDQY-UHFFFAOYSA-N Y
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Rolicyclidine (PCPy) is a dissociative anesthetic that is similar in effects to phencyclidine, but is slightly less potent and has fewer stimulant effects.[2] It instead produces a sedative effect described as being somewhat similar to a barbiturate, but with additional PCP-like dissociative, anaesthetic and hallucinogenic effects.[3] Due to its similarity in effects to PCP, PCPy was placed into the Schedule I list of illegal drugs in the 1970s, although it has never been widely abused and is now little known.
See also
References
- ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
- ^ Kalir A, Edery H, Pelah Z, Balderman D, Porath G (May 1969). "1-Phenycycloalkylamine derivatives. II. Synthesis and pharmacological activity". Journal of Medicinal Chemistry. 12 (3): 473–7. doi:10.1021/jm00303a030. PMID 4977945.
- ^ DEA Microgram Bulletin, 8, 143, 1975
General anesthetics (N01A) |
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| Inhalational | |
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| Injection | |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Arylcyclo‐ hexylamines |
- Ketamine-related: 2-Bromodeschloroketamine (2-BDCK; bromoketamine)
- 2-Fluorodeschloroketamine (2-FDCK)
- 2-FXPr
- 3-Fluorodeschloroketamine (3-FDCK)
- A-NK
- Arketamine ((R)-ketamine)
- Blixeprodil (GM-1020; (R)-4-FDCK)
- Deoxymethoxetamine (DMXE)
- Deschloroketamine (DXE, DCK)
- Ethketamine (N-ethylnorketamine, NENK)
- Esketamine ((S)-ketamine)
- Fluorexetamine (3-FXE)
- Hydroxetamine (HXE)
- Ketamine (K)
- Methoxetamine (MXE)
- Methoxmetamine (MXM, MXME)
- Methoxypropamine (MXPr)
- Methoxyketamine
- Methoxisopropamine (MXiPr)
- Norketamine (NK)
- SN-35210
- TFMDCK
- Tiletamine
- Tilmetamine
- XW10508
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| Adamantanes | |
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| Diarylethylamines |
- Diphenidine (1,2-DEP, DPD)
- Ephenidine (NEDPA, EPE)
- Fluorolintane (2-FPPP)
- Methoxphenidine (MXP)
- NPDPA (isopropylphenidine, isophenidine)
- Remacemide
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| Morphinans | |
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| Inhalants | |
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| Others |
- 2-MDP (U-23807A)
- 8A-PDHQ
- Alkyl nitrites/poppers (e.g., amyl nitrite)
- Aptiganel (Cerestat; CNS-1102)
- CNS-5161
- Delucemine
- Dexoxadrol
- Dizocilpine (MK-801)
- Etoxadrol
- F-17475
- Midafotel (CPPene)
- NEFA
- Neramexane
- PD-137889
- Perzinfotel
- Selfotel (CGS-19755)
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- See also: Hallucinogens
- Ionotropic glutamate receptor modulators
- List of hallucinogens
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Dopamine receptor modulators |
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| D1-like | | Agonists |
- Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959
- Trepipam
- Zelandopam
- Dihydrexidine derivatives: A-77636
- A-86929
- Adrogolide (ABT-431, DAS-431)
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine
- Phenethylamines: BCO-001
- Deoxyepinephrine (N-methyldopamine, epinine)
- Dipropyldopamine (DPDA)
- Dopamine
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- Lu AE04621
- Melevodopa
- L-Phenylalanine
- L-Tyrosine
- XP21279
- Others: A-68930
- Apomorphine
- Isocorypalmine
- Lu AF28996
- Nuciferine
- PF-06412562
- PF-6649751
- PF 6669571
- Propylnorapomorphine
- Rotigotine
- SKF-89,145
- SKF-89,626
- Stepholidine
- Tavapadon
- Tetrahydropalmatine
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| PAMs |
- Tetrahydroisoquinolines: DETQ
- DPTQ
- Glovadalen
- Mevidalen
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| Antagonists |
- Others: Berupipam
- Ecopipam
- EEDQ
- Metitepine (methiothepin)
- Odapipam
- Perlapine
- SCH-23390
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| D2-like | | Agonists |
- Aminotetralins: 5-OH-DPAT
- 7-OH-DPAT
- 8-OH-PBZI
- CHF-1024
- Nolomirole
- Rotigotine
- UH-232
- Dihydrexidine derivatives: 2-OH-NPA
- Ciladopa
- Dihydrexidine
- Dinoxyline
- N,N-Propyldihydrexidine
- Phenethylamines: Deoxyepinephrine (N-methyldopamine, epinine)
- Dipropyldopamine (DPDA)
- Dopamine
- Dopexamine
- Etilevodopa
- Ibopamine
- L-DOPA (levodopa)
- Lu AE04621
- L-Phenylalanine
- RU-24213
- L-Tyrosine
- Melevodopa
- XP21279
- Atypical antipsychotics: Alentemol (U-66444B)
- Aripiprazole (+sertraline)
- Aripiprazole lauroxil
- Bifeprunox
- Brexpiprazole
- Brilaroxazine
- Cariprazine
- F-15063
- Lumateperone
- Norclozapine
- Others: 3-PPP
- A-412997
- ABT-670
- ABT-724
- Adrafinil
- Aplindore
- Apomorphine
- Arketamine
- Armodafinil
- BP-897
- Captodiame
- CP-226,269
- Debenzergoline
- Dizocilpine
- Esketamine
- Etrabamine
- Flibanserin
- 7-Hydroxyropinirole (SK&F-89124)
- Ketamine
- Lu AF28996
- Matsupexole
- Modafinil
- Naxagolide
- OSU-6162
- Pardoprunox
- PD-128,907
- PD-168,077
- PF-219,061
- PF-592,379
- Phencyclidine
- Piribedil
- Pramipexole
- Preclamol
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Roxindole
- S32504
- Salvinorin A
- SKF-39315
- SKF-83,959
- Sumanirole
- Talipexole
- Umespirone
- WAY-100,635
- XC-130
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| Antagonists |
- Others: 3-PPP
- Alpiropride
- Azapride
- Bromerguride
- Bromocriptine
- Buspirone
- Carmoxirole
- Desmethoxyfallypride
- EEDQ
- F-15063
- Fallypride
- Fananserin
- Fenfluramine
- Iodobenzamide
- Isocorypalmine
- L-741,626
- L-745,870
- Levofenfluramine
- LEK-8829
- Metitepine (methiothepin)
- N-Methylspiperone
- Nafadotride
- Nuciferine
- Ordopidine
- PNU-99,194
- Pridopidine
- Raclopride
- Sarizotan
- SB-277,011-A
- Seridopidine
- Sonepiprazole
- Spiroxatrine
- Stepholidine
- SV-293
- Tetrahydropalmatine
- Tiapride
- UH-232
- XC-130
- Yohimbine
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- See also: Receptor/signaling modulators
- Adrenergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
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Ionotropic glutamate receptor modulators |
|---|
| AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor | |
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| KARTooltip Kainate receptor | |
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| NMDARTooltip N-Methyl-D-aspartate receptor |
- Unsorted: Allosteric modulators: AGN-241751
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- See also: Receptor/signaling modulators
- Metabotropic glutamate receptor modulators
- Glutamate metabolism/transport modulators
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